Histologic, Histomorphometric, and Clinical Analysis of the Effects of Growth Factors in a Fibrin Network Used in Maxillary Sinus Augmentation

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Cinar İ. Ç., Gultekin B., Saglanmak A., Yalcin S., Olgac V., Mijiritsky E.

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH, vol.17, 2020 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 17
  • Publication Date: 2020
  • Doi Number: 10.3390/ijerph17061918
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Social Sciences Citation Index (SSCI), Scopus, Agricultural & Environmental Science Database, Aqualine, Aquatic Science & Fisheries Abstracts (ASFA), CAB Abstracts, EMBASE, Geobase, MEDLINE, Pollution Abstracts, Veterinary Science Database, Directory of Open Access Journals
  • Keywords: beta-tricalcium phosphate, histomorphometry, maxillary sinus lifting, mineralized plasmatic matrix, volume change, BETA-TRICALCIUM PHOSPHATE, PLATELET-RICH FIBRIN, AUTOGENOUS BONE, FLOOR AUGMENTATION, BOVINE BONE, VOLUMETRIC CHANGES, CALCIUM-PHOSPHATE, RESORPTION RATE, GRAFT MATERIAL, FOLLOW-UP
  • Istanbul University Affiliated: Yes


This randomized controlled clinical trial evaluated the effect of mineralized plasmatic matrix (MPM), comprised of synthetic graft and platelet concentrates, on new bone formation and volume stability over time in maxillary sinus lifting (MSL). Unilateral MSL was performed in 20 patients with either beta-tricalcium phosphate (beta-TCP) or MPM grafts (10 sinuses each). Six months postsurgery, specimens were obtained with a trephine bur prior to implant placement in 39 cases. Volumetric changes in sinus augmentation were analyzed between 1 week (T-I) and 6 months (T-II) postsurgery. Histomorphometric and histological analyses of biopsy samples revealed mean new bone percentages of 35.40% +/- 9.09% and 26.92% +/- 7.26% and residual graft particle areas of 23.13% +/- 6.16% and 32.25% +/- 8.48% in the MPM and beta-TCP groups, respectively (p < 0.05). The mean soft-tissue areas in the MPM and beta-TCP groups were 41.48% +/- 8.41% and 40.83% +/- 8.86%, respectively (p > 0.05). Graft reductions between baseline and 6-months postprocedure in the beta-TCP and MPM groups were 17.12% +/- 13.55% and 14.41% +/- 12.87%, respectively, with significant graft volume reduction observed in both groups (p < 0.05) while there is no significant difference between MPM and beta-TCP groups (p > 0.05). Thus, MPM, representing growth factors in a fibrin network, increases new bone formation and has acceptable volume stability in MSL procedures