Biological Agents in Familial Mediterranean Fever Focusing on Colchicine Resistance and Amyloidosis

Sozeri B., Kasapcopur O.

CURRENT MEDICINAL CHEMISTRY, vol.22, no.16, pp.1986-1991, 2015 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 22 Issue: 16
  • Publication Date: 2015
  • Doi Number: 10.2174/0929867322666150311152300
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1986-1991
  • Istanbul University Affiliated: Yes


Familial Mediterranean fever (FMF) is the most common hereditary autoinflammatory syndrome. FMF is caused by mutations in the MEFV gene which encodes the pyrin protein. FMF is characterized by sporadic, paroxysmal attacks of fever and serosal inflammation, lasting 1-3 days. Patients may develop renal amyloidosis. Colchicine prevents attacks and renal amyloidosis. 5% to 10% of the patients with FMF are resistant or intolerant to colchicine. Colchicine resistant patients may receive biological therapies. Anti-interleukin-1 drugs are the most important agents of biological treatments. In this review, colchicine resistance and treatment options will be evaluated.