Association of HLA-DRB1 Alleles and Autoimmune Hepatitis in Turkish Patients

Kekik, Çiğdem; Seyhun, Yalcin; Karahan, Gonca; Pinarbasi, Binnur; Demir, Kadir; Kaymakoglu, Sabahattin; Carin, Mahmut

doi:10.5174/tutfd.2009.02045.1

Association of HLA-DRB1 Alleles and Autoimmune Hepatitis in Turkish Patients

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Kekik C., Seyhun Y., Karahan G. E., Pinarbasi B., Demir K., Kaymakoglu S., ...More

TRAKYA UNIVERSITESI TIP FAKULTESI DERGISI, vol.27, no.3, pp.253-256, 2010 (SCI-Expanded)

Publication Type: Article / Article
Volume: 27 Issue: 3
Publication Date: 2010
Doi Number: 10.5174/tutfd.2009.02045.1
Journal Name: TRAKYA UNIVERSITESI TIP FAKULTESI DERGISI
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
Page Numbers: pp.253-256
Istanbul University Affiliated: Yes

Abstract

Objectives: Autoimmune hepatitis (AIH) which is characterized by hypergammaglobulinemia and a wide range of circulating auto antibodies is a necro-inflammatory liver disease of unknown aetiology. Immunogenetic studies have shown the association of autoimmunity with HLA (Human Leukocyte Antigen) alleles. Furthermore, they have shown a decrease in the expression of HLA antigens on lymphocyte surface and a dysregulation of gene expression arranged by HLA. A significant association is found between AIH and HLA-DRB1(star)03, (star)04 and (star)13 alleles in various studies. We performed HLA-DRB1 genotyping in Turkish patients with AIH.