Association of HLA-DRB1 Alleles and Autoimmune Hepatitis in Turkish Patients

Kekik C., Seyhun Y., Karahan G. E., Pinarbasi B., Demir K., Kaymakoglu S., ...Daha Fazla

TRAKYA UNIVERSITESI TIP FAKULTESI DERGISI, cilt.27, sa.3, ss.253-256, 2010 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 27 Sayı: 3
  • Basım Tarihi: 2010
  • Doi Numarası: 10.5174/tutfd.2009.02045.1
  • Dergi Adı: TRAKYA UNIVERSITESI TIP FAKULTESI DERGISI
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.253-256
  • İstanbul Üniversitesi Adresli: Evet

Özet

Objectives: Autoimmune hepatitis (AIH) which is characterized by hypergammaglobulinemia and a wide range of circulating auto antibodies is a necro-inflammatory liver disease of unknown aetiology. Immunogenetic studies have shown the association of autoimmunity with HLA (Human Leukocyte Antigen) alleles. Furthermore, they have shown a decrease in the expression of HLA antigens on lymphocyte surface and a dysregulation of gene expression arranged by HLA. A significant association is found between AIH and HLA-DRB1(star)03, (star)04 and (star)13 alleles in various studies. We performed HLA-DRB1 genotyping in Turkish patients with AIH.