Retrospective analysis of children with uveitis treated with infliximab.

Tugal-Tutkun, Nuriye; Ayranci, Oezen; Kasapcopur, Özgür; Kir, Nur

doi:10.1016/j.jaapos.2008.08.007

Retrospective analysis of children with uveitis treated with infliximab.

Tugal-Tutkun I., Ayranci O., Kasapcopur O., Kir N.

Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus, cilt.12, sa.6, ss.611-3, 2008 (SCI-Expanded)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 12 Sayı: 6
Basım Tarihi: 2008
Doi Numarası: 10.1016/j.jaapos.2008.08.007
Dergi Adı: Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.611-3
İstanbul Üniversitesi Adresli: Evet

Özet

Tumor necrosis factor-alpha (TNF-alpha) antagonists have been successfully used in refractory cases of pediatric uveitis.(1-7) We report our experience with the monoclonal anti-TNF-alpha antibody infliximab in the treatment of uveitis in 20 children. Twenty children with noninfectious uveitis were treated with infliximab as an initial line of immunomodulatory therapy (4 children) or for uncontrolled intraocular inflammation despite aggressive immunosuppressive therapy (16 children). Intraocular inflammation was controlled in the short term in all children; resistance developed in 4 children after long-term therapy.