The Role of PPAR-gamma C161T Polymorphism in Colorectal Cancer Susceptibility

Kurnaz-Gomleksiz O., Torun B. C., Isbir T., Bulut T., Sokucu N., Yilmaz-Aydogan H., ...Daha Fazla

IN VIVO, cilt.36, sa.4, ss.1911-1915, 2022 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 36 Sayı: 4
  • Basım Tarihi: 2022
  • Doi Numarası: 10.21873/invivo.12911
  • Dergi Adı: IN VIVO
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, EMBASE, MEDLINE
  • Sayfa Sayıları: ss.1911-1915
  • Anahtar Kelimeler: PPARg C161T polymorphism, colorectal cancer, Turkish population, ACTIVATED RECEPTOR-GAMMA, COMMON POLYMORPHISMS, RISK, GENES, ASSOCIATIONS, PRO12ALA, COLON
  • İstanbul Üniversitesi Adresli: Evet

Özet

Background/Aim: This study aimed to determine the role of the peroxisome proliferator-activated receptor gamma (PPARg) C161T genotype and allele frequencies in predisposition to colorectal cancer (CRC). Patients and Methods: PPARg C161T (His447His; rs3856806) gene polymorphisms were determined by polymerase chain reaction-restriction fragment length polymorphism analysis in patients with CRC (n=101) and controls (n=238). Results: The T161 allele (CT+TT genotypes) of PPARg C161T polymorphism was associated with CRC development (p<0.001; OR=3.239, 95%CI=1.997-5.252). Subgroup analysis showed that the T161 allele was associated with a 3.056-fold increased risk for colon cancer (CC) (p<0.001; 95%CI=1.709-5.464) and 3.529-fold increased risk for rectal cancer (RC) (p<0.001; 95%C=1.784-6.981). Frequencies of the T161 allele were also higher in total CRC and CC patients with poorly differentiated tumors (p<0.001, c(2)=30,601, OR=3.109; 95%CI=1.970-4.906 and p<0.001, Fisher exact test, respectively). Conclusion: PPARg T161 allele carriers have increased risk for developing CRC.