Lactoferrin Levels in the Gastric Tissue of Helicobacter pylori-Positive and -Negative Patients and Its Effect on Anemia

Dogan Y., Erkan T., Onal Z., Usta M., Dogusoy G., Cokugras F. C., ...Daha Fazla

MEDIATORS OF INFLAMMATION, cilt.2012, 2012 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 2012
  • Basım Tarihi: 2012
  • Doi Numarası: 10.1155/2012/214581
  • Dergi Adı: MEDIATORS OF INFLAMMATION
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • İstanbul Üniversitesi Adresli: Evet

Özet

Aim. To determine gastric tissue lactoferrin (Lf) levels of Helicobacter pylori- (Hp-) positive and -negative patients and its effect on anemia. Methods. Cases in which initial presentation was of abdominal pain and that were Hp-positive at endoscopy were included. Hp-positive cases and -negative controls were divided into two groups. Results. The study included 64 cases (average: 10.2 +/- 0.4 years, 39 male and 25 female). Lf levels were subsequently studied on 61 cases. 45 (73.8%) of these were Hp-positive, while 16 (22.2%) were Hp-negative. In Hp-positive cases, mean staining percentages and density of glands in the antral mucosa were 45.5 +/- 4.7% and 1.9 +/- 0.1, respectively. Hp-negative cases showed significantly different values of 17.8 +/- 4.5% and 1.3 +/- 0.2, respectively. Hemoglobin and serum ferritin values of Hp-positive cases were 12.7 +/- 0.2 g/dL and 32.5 +/- 2ng/mL, but these were comparable with Hp-negative cases (12.6 +/- 0.1 g/dL and 30.7 +/- 4.4ng/mL). Conclusions. Tissue Lf was significantly higher in Hp-positive cases compared to Hp-negative cases, but no difference was observed between the two groups with regards to hemoglobin and ferritin level. As a result, it is difficult to say that this rise in Lf plays a role in the development of iron deficiency anemia in Hp-positive patients.