The flavonoid apigenin reduces prostate cancer CD44(+) stem cell survival and migration through PI3K/Akt/NF-kappa B signaling

ERDOGAN S., DOĞANLAR O., DOĞANLAR Z. B., SERTTAŞ R., Turkekul K., DIBIRDIK İ., ...More

LIFE SCIENCES, vol.162, pp.77-86, 2016 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 162
  • Publication Date: 2016
  • Doi Number: 10.1016/j.lfs.2016.08.019
  • Journal Name: LIFE SCIENCES
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.77-86
  • Istanbul University Affiliated: No

Abstract

Aims: Cancer stem cells (CSCs) are involved in drug resistance, metastasis and recurrence of cancers. The efficacy of apigenin on cell survival, apoptosis, migration and stemness properties were analyzed in CSCs.