Investigation of MMP-9 rs3918242 and TIMP-2 rs8179090 polymorphisms in renal cell carcinoma tissues

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Caykara B., Alsaadoni H., Pence S., Pence H. H., Otunctemur A.

TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI, vol.45, no.4, pp.429-434, 2020 (SCI-Expanded, Scopus, TRDizin)

• Publication Type: Article / Article
• Volume: 45 Issue: 4
• Publication Date: 2020
• Doi Number: 10.1515/tjb-2019-0048
• Journal Name: TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI
• Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, EMBASE, TR DİZİN (ULAKBİM)
• Page Numbers: pp.429-434
• Istanbul University Affiliated: Yes

Abstract

Background: The proteolytic activities of matrix metalloproteinases (MMP), cell surface enzymes degrading extracellular matrix, is inhibited by matrix metalloproteinase tissue inhibitors (TIMP). We aim to detect the effects of MMP-9 rs3918242 and TIMP-2 rs8179090 gene variations in renal cell cancer transformation.