Association of Monocyte Chemotactic Protein-1 and CC Chemokine Receptor 2 Gene Variants with Preeclampsia

Agachan B. , Attar R., Isbilen E., Aydogan H. Y. , Sozen S., Gurdol F., ...Daha Fazla

JOURNAL OF INTERFERON AND CYTOKINE RESEARCH, cilt.30, sa.9, ss.673-676, 2010 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 30 Konu: 9
  • Basım Tarihi: 2010
  • Doi Numarası: 10.1089/jir.2010.0008
  • Sayfa Sayıları: ss.673-676


Preeclampsia complicates 10% of pregnancies in developing countries. It is one of the leading causes of maternal and fetal/neonatal mortality and morbidity worldwide. It has been suggested that maladaptation of the maternal immune response during pregnancy might be a causal factor for preeclampsia. According to immune maladaptation hypothesis, preeclampsia is due to an inappropriate regulation of normally Th2-deviated maternal immune responses, leading to a shift toward harmful Th1 immunity. Several studies indicate that monocyte chemotactic protein-1 (MCP-1) and CC chemokine receptor 2 (CCR2) are involved in Th1 and Th2 immunity. In this study, we investigated the association between MCP-1 A-2518G and CCR2-V64I polymorphisms and preeclampsia. One hundred eighty preeclamptic pregnant women and 145 healthy controls were included in the study. We observed that in preeclamptic women, MCP-1 G: CCR2 Val haplotype was significantly higher when compared with other haplotypes. In conclusion, we stated that MCP-1 and CCR2 gene variants might be associated with preeclampsia.