A free radical scavenger (Tempol) and its effect on intimal hyperplasia of vein grafts in rats

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Turkmen A., Dogan M., Temel M.

ULUSAL TRAVMA VE ACIL CERRAHI DERGISI-TURKISH JOURNAL OF TRAUMA & EMERGENCY SURGERY, vol.24, no.5, pp.379-386, 2018 (SCI-Expanded)

• Publication Type: Article / Article
• Volume: 24 Issue: 5
• Publication Date: 2018
• Doi Number: 10.5505/tjtes.2017.80281
• Journal Name: ULUSAL TRAVMA VE ACIL CERRAHI DERGISI-TURKISH JOURNAL OF TRAUMA & EMERGENCY SURGERY
• Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
• Page Numbers: pp.379-386
• Istanbul University Affiliated: Yes

Abstract

BACKGROUND: Reversed vein grafting exposes the vessel to a period of ischemia, reperfusion and subsequent reactive oxygen species, which may damage endothelial tissue, smooth muscle cell proliferation and later the development of intimal hyperplasia. Tempol is a free radical scavenger that permeates biological membranes. This study investigates the effects of a free radical scavenger (Tempol) on intimal hyperplasia of femoral vein grafts and the level of reactive oxygen species in rats.