Reactive extraction of protocatechuic acid by di-n-octylamine and optimisation with Box-Behnken design

Isayev I., DEMİR Ö., GÖK A., KIRBAŞLAR Ş. İ.

INDIAN CHEMICAL ENGINEER, vol.65, no.6, pp.495-510, 2023 (ESCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 65 Issue: 6
  • Publication Date: 2023
  • Doi Number: 10.1080/00194506.2023.2214150
  • Journal Name: INDIAN CHEMICAL ENGINEER
  • Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus, Academic Search Premier, Aerospace Database, Communication Abstracts, INSPEC, Metadex, Civil Engineering Abstracts
  • Page Numbers: pp.495-510
  • Keywords: di-n-octylamine, optimisation, Protocatechuic acid, reactive extraction, secondary amine
  • Istanbul University Affiliated: No

Abstract

Protocatechuic acid (PCA) is typically produced by microbial fermentation. Its separation from fermentation broth or aqueous waste streams is of great importance. This study aimed to recover PCA by a secondary amine namely di-n-octylamine (DOA). Three organic solvents, namely isobutyl methyl ketone, propyl acetate and linalool, were used with DOA. Important extraction parameters were optimised by response surface methodology. DOA/isobutyl methyl ketone system showed 95.84% extraction efficiency under the optimum conditions. The maximum E% of the DOA/propyl acetate system was 86.73%. The maximum E% of the DOA/linalool system was 81.71%. Additionally, a thermodynamic study was carried out, and the reactions were endothermic.