A novel mutation in EED associated with overgrowth


Cohen A. S. A. , Tuysuz B. , SHEN Y., BHALLA S. K. , Jones S. J. M. , Gibson W. T.

JOURNAL OF HUMAN GENETICS, cilt.60, ss.339-342, 2015 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 60 Konu: 6
  • Basım Tarihi: 2015
  • Doi Numarası: 10.1038/jhg.2015.26
  • Dergi Adı: JOURNAL OF HUMAN GENETICS
  • Sayfa Sayıları: ss.339-342

Özet

In a patient suspected clinically to have Weaver syndrome, we ruled out mutations in EZH2 and NSD1, then identified a previously undescribed de novo mutation in EZH2's partner protein EED. Both proteins are members of the Polycomb Repressive Complex 2 that maintains gene silencing. On the basis of the similarities of the patient's phenotype to Weaver syndrome, which is caused by de novo mutations in EZH2, and on other lines of evidence including mouse Eed hypomorphs, we characterize this mutation as probably pathogenic for a Weaver-like overgrowth syndrome. This is the first report of overgrowth and related phenotypes associated with a constitutional mutation in human EED.