Effect of heme oxygenase-1 induction by octreotide on TNBS-induced colitis

Erbil, Yeşim; Giris, MURAT; Abbasoglu, SEMRA; BARBAROS, Umut; YANIK, Burcu; NECEFLI, Ahmet; Olgaç, NECAT; TOKER, Guelcin

doi:10.1111/j.1440-1746.2007.04838.x

Effect of heme oxygenase-1 induction by octreotide on TNBS-induced colitis

Erbil Y., Giris M., Abbasoglu S. D., BARBAROS U., YANIK B. T., NECEFLI A., ...Daha Fazla

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, cilt.22, sa.11, ss.1852-1858, 2007 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 22 Sayı: 11
Basım Tarihi: 2007
Doi Numarası: 10.1111/j.1440-1746.2007.04838.x
Dergi Adı: JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.1852-1858
İstanbul Üniversitesi Adresli: Evet

Özet

Background and Aim: Ulcerative colitis is a chronic inflammatory disease of the colon and rectum. Although the precise etiology of ulcerative colitis remains unknown, it is believed to involve an abnormal host response to endogenous or environmental antigens, genetic factors, and oxidative damage. The aim of the present study was to investigate whether heme oxygenase-1 (HO-1) induction by octreotide could protect against oxidative and inflammatory damage from induced colitis.