Effect of heme oxygenase-1 induction by octreotide on TNBS-induced colitis

Erbil, Yeşim; Giris, MURAT; Abbasoglu, SEMRA; BARBAROS, Umut; YANIK, Burcu; NECEFLI, Ahmet; Olgaç, NECAT; TOKER, Guelcin

doi:10.1111/j.1440-1746.2007.04838.x

Effect of heme oxygenase-1 induction by octreotide on TNBS-induced colitis

Erbil Y., Giris M., Abbasoglu S. D., BARBAROS U., YANIK B. T., NECEFLI A., ...More

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, vol.22, no.11, pp.1852-1858, 2007 (SCI-Expanded, Scopus)

Publication Type: Article / Article
Volume: 22 Issue: 11
Publication Date: 2007
Doi Number: 10.1111/j.1440-1746.2007.04838.x
Journal Name: JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.1852-1858
Istanbul University Affiliated: Yes

Abstract

Background and Aim: Ulcerative colitis is a chronic inflammatory disease of the colon and rectum. Although the precise etiology of ulcerative colitis remains unknown, it is believed to involve an abnormal host response to endogenous or environmental antigens, genetic factors, and oxidative damage. The aim of the present study was to investigate whether heme oxygenase-1 (HO-1) induction by octreotide could protect against oxidative and inflammatory damage from induced colitis.