Strategies of targeting the extracellular domain of RON tyrosine kinase receptor for cancer therapy and drug delivery

Zarei O., Benvenuti S., Ustun-Alkan F., Hamzeh-Mivehroud M., Dastmalchi S.

JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, vol.142, no.12, pp.2429-2446, 2016 (SCI-Expanded) identifier identifier identifier


Cancer is one of the most important life-threatening diseases in the world. The current efforts to combat cancer are being focused on molecular-targeted therapies. The main purpose of such approaches is based on targeting cancer cell-specific molecules to minimize toxicity for the normal cells. RON (Recepteur d'Origine Nantais) tyrosine kinase receptor is one of the promising targets in cancer-targeted therapy and drug delivery.