Strategies of targeting the extracellular domain of RON tyrosine kinase receptor for cancer therapy and drug delivery


Zarei O., Benvenuti S., Ustun-Alkan F. , Hamzeh-Mivehroud M., Dastmalchi S.

JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, vol.142, no.12, pp.2429-2446, 2016 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Review
  • Volume: 142 Issue: 12
  • Publication Date: 2016
  • Doi Number: 10.1007/s00432-016-2214-4
  • Title of Journal : JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
  • Page Numbers: pp.2429-2446

Abstract

Cancer is one of the most important life-threatening diseases in the world. The current efforts to combat cancer are being focused on molecular-targeted therapies. The main purpose of such approaches is based on targeting cancer cell-specific molecules to minimize toxicity for the normal cells. RON (Recepteur d'Origine Nantais) tyrosine kinase receptor is one of the promising targets in cancer-targeted therapy and drug delivery.