Strategies of targeting the extracellular domain of RON tyrosine kinase receptor for cancer therapy and drug delivery

Zarei, Omid; Benvenuti, Silvia; Ustun-Alkan, Fulya; Hamzeh-Mivehroud, Maryam; Dastmalchi, Siavoush

doi:10.1007/s00432-016-2214-4

Strategies of targeting the extracellular domain of RON tyrosine kinase receptor for cancer therapy and drug delivery

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Zarei O., Benvenuti S., Ustun-Alkan F., Hamzeh-Mivehroud M., Dastmalchi S.

JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, vol.142, no.12, pp.2429-2446, 2016 (SCI-Expanded)

Publication Type: Article / Review
Volume: 142 Issue: 12
Publication Date: 2016
Doi Number: 10.1007/s00432-016-2214-4
Journal Name: JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.2429-2446
Istanbul University Affiliated: Yes

Abstract

Cancer is one of the most important life-threatening diseases in the world. The current efforts to combat cancer are being focused on molecular-targeted therapies. The main purpose of such approaches is based on targeting cancer cell-specific molecules to minimize toxicity for the normal cells. RON (Recepteur d'Origine Nantais) tyrosine kinase receptor is one of the promising targets in cancer-targeted therapy and drug delivery.