Comprasion of sensitivity of fine needle aspiration biopsy and ultrasonography according to nodule size in preoperative diagnosis of thyroid cancer
16. Annual Meeting of the European Society of Surgery, İstanbul, Türkiye, 22 - 24 Kasım 2012, cilt.44, ss.13, (Tam Metin Bildiri)
- Yayın Türü: Bildiri / Tam Metin Bildiri
- Cilt numarası: 44
- Basıldığı Şehir: İstanbul
- Basıldığı Ülke: Türkiye
- Sayfa Sayıları: ss.13
- İstanbul Üniversitesi Adresli: Evet
Özet
Background&Aims: To investigate the effect of nodule size on
the sensitivity of fine needle aspiration biopsy (FNAB) and ultrasonography (US) in preoperative diagnosis of thyroid cancer.
Methods: A total of 726 nodules were evaluated both with FNAB
and US. The sensitivity, specificity and accuracy of both FNAB and US
according to nodule size were determined.
Results: The overall sensitivity, specificity and accuracy of FNAB
was 62.4, 81 and 71 %, respectively. The sensitivity of FNAB decreased
in nodules ≥ 3 cm compared to nodules < 3 cm (34 vs. 71 %, p=0.0001).
The sensitivity of FNAB was lower in multinodular goiter patients
compared to that with solitary nodules, the difference was not statistically significant (62 vs. 71 %, p=0.1). Solid hypoechoic structure,
microcalcifications and irregular margin in a nodule at US was significantly associated with thyroid cancer. The sensitivity, specificity
and accuracy of these three features ranged between 26–69, 38–87
and 54–58 %, respectively. The sensitivity, specificity and accuracy of
sonographic features showed no significant difference according to
the nodule size.
Conclusion: The sensitivity of thyroid FNAB is significantly lower
in nodules ≥ 3 cm, whereas US have the same sensitivity for nodules
both ≥ 3 and < 3 cm. In nodules ≥ 3 cm with benign FNAB result and
suspicious sonographic features, the risk of a false negative FNAB
result should be kept in mind.