Comprasion of sensitivity of fine needle aspiration biopsy and ultrasonography according to nodule size in preoperative diagnosis of thyroid cancer

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Özgür I., Işcan A. Y., Fırat P., Yekeler E., Tunca F., Şenyürek Y., ...Daha Fazla

16. Annual Meeting of the European Society of Surgery, İstanbul, Türkiye, 22 - 24 Kasım 2012, cilt.44, ss.13

  • Yayın Türü: Bildiri / Tam Metin Bildiri
  • Cilt numarası: 44
  • Basıldığı Şehir: İstanbul
  • Basıldığı Ülke: Türkiye
  • Sayfa Sayıları: ss.13
  • İstanbul Üniversitesi Adresli: Evet

Özet

Background&Aims: To investigate the effect of nodule size on the sensitivity of fine needle aspiration biopsy (FNAB) and ultrasonography (US) in preoperative diagnosis of thyroid cancer. Methods: A total of 726 nodules were evaluated both with FNAB and US. The sensitivity, specificity and accuracy of both FNAB and US according to nodule size were determined. Results: The overall sensitivity, specificity and accuracy of FNAB was 62.4, 81 and 71 %, respectively. The sensitivity of FNAB decreased in nodules ≥ 3 cm compared to nodules < 3 cm (34 vs. 71 %, p=0.0001). The sensitivity of FNAB was lower in multinodular goiter patients compared to that with solitary nodules, the difference was not statistically significant (62 vs. 71 %, p=0.1). Solid hypoechoic structure, microcalcifications and irregular margin in a nodule at US was significantly associated with thyroid cancer. The sensitivity, specificity and accuracy of these three features ranged between 26–69, 38–87 and 54–58 %, respectively. The sensitivity, specificity and accuracy of sonographic features showed no significant difference according to the nodule size. Conclusion: The sensitivity of thyroid FNAB is significantly lower in nodules ≥ 3 cm, whereas US have the same sensitivity for nodules both ≥ 3 and < 3 cm. In nodules ≥ 3 cm with benign FNAB result and suspicious sonographic features, the risk of a false negative FNAB result should be kept in mind.