Possible Associations of APE1 Polymorphism with Susceptibility and HOGG1 Polymorphism with Prognosis in Gastric Cancer


Canbay E., Agachan B., Gulluoglu M., Isbir T., Balik E., Yamaner S., ...More

ANTICANCER RESEARCH, vol.30, no.4, pp.1359-1364, 2010 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 30 Issue: 4
  • Publication Date: 2010
  • Journal Name: ANTICANCER RESEARCH
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1359-1364
  • Keywords: DNA repair genes, polymorphism, gastric cancer, NUCLEOTIDE EXCISION-REPAIR, DNA-REPAIR, FUNCTIONAL-CHARACTERIZATION, SER326CYS POLYMORPHISM, GENETIC-POLYMORPHISM, CHINESE POPULATION, COLORECTAL-CANCER, LUNG-CANCER, RISK, XRCC1
  • Istanbul University Affiliated: Yes

Abstract

Background: Multiple genetic and epigenetic alterations in several genes are implicated in the multistep process of human gastric carcinogenesis. In this study, we examined the polymorphisms of six DNA repair genes: APE1, HOGG1, XRCC1, XRCC3, XPD, and XPG in patients with gastric cancer (GC). Patients and Methods: Forty patients with GC and 247 controls were included in this study. DNA polymorphisms were determined by polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) method. Results: The frequency of the Asp/Glu genotype and Glu allele of APE1 in patients with GC was significantly higher than in the control group (p=0.05). We also observed a higher frequency of the Ser/Ser genotype of HOGG1 in grade III tumors, and in tumors with metastasis to adjacent tissue and solid organs (p<0.05). Conclusion: Our results suggest that (i) APE1 gene polymorphism may be associated with GC risk and (ii) HOGG1 gene polymorphism may be informative in the prognosis of GC.