Comparison of new and classical point mutations associated with clarithromycin resistance in Helicobacter pylori strains isolated from dyspeptic patients and their effects on phenotypic clarithromycin resistance

KOCAZEYBEK, Bekir; Sakli, Merve; Yuksel, Pelin; DEMİRCİ, MEHMET; Caliskan, Reyhan; Sarp, Tevhide; Saribas, Suat; DEMİRYAS, SÜLEYMAN; Kalayci, Fatma; ÇAKAN, HÜSEYİN; KIRKOYUN UYSAL, Hayriye; Gareayaghi, Nesrin; ERGİN, SEVGİ; ERZİN, Yusuf; BAL, Kadir; TAŞÇI, İhsan; BAHAR TOKMAN, HRİSİ

doi:10.1099/jmm.0.000944

Comparison of new and classical point mutations associated with clarithromycin resistance in Helicobacter pylori strains isolated from dyspeptic patients and their effects on phenotypic clarithromycin resistance

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KOCAZEYBEK B. S., Sakli M. K., Yuksel P., DEMİRCİ M., Caliskan R., Sarp T. Z., ...More

JOURNAL OF MEDICAL MICROBIOLOGY, vol.68, no.4, pp.566-573, 2019 (SCI-Expanded)

Publication Type: Article / Article
Volume: 68 Issue: 4
Publication Date: 2019
Doi Number: 10.1099/jmm.0.000944
Journal Name: JOURNAL OF MEDICAL MICROBIOLOGY
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.566-573
Keywords: Helicobacter pylori, A2115G, A2144T and G2141A, point mutations, clarithromycin, RIBOSOMAL-RNA GENE, ANTIBIOTIC-RESISTANCE, MACROLIDE RESISTANCE, METRONIDAZOLE, PREVALENCE, ASSAY, RISK
Istanbul University Affiliated: Yes

Abstract

Purpose. We aimed to investigate the presence of three recently identified point mutations (A2115G, G2141A and A2144T) of the 23 S rRNA gene and compare them with the three most frequently encountered point mutations (A2142G, A2142C and A2143G) in Helicobacter pylori strains in Turkey.