TERPENOIDS FROM SALVIA-SCLAREA

ULUBELEN A., TOPCU G., ERIS C., SONMEZ U., KARTAL M., KURUCU S., ...More

PHYTOCHEMISTRY, vol.36, no.4, pp.971-974, 1994 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 36 Issue: 4
  • Publication Date: 1994
  • Doi Number: 10.1016/s0031-9422(00)90474-6
  • Journal Name: PHYTOCHEMISTRY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.971-974
  • Keywords: SALVIA SCLAREA, LABIATAE, SESQUITERPENES, DITERPENES, TRITERPENES, FLAVONOIDS, ANTIMICROBIAL ACTIVITY, ABIETANE DITERPENOIDS
  • Istanbul University Affiliated: Yes

Abstract

From an acetone extract of the whole plant Salvia sclarea, seven known diterpenes, sclareol, manool, salvipisone, ferruginol, microstegiol, candidissiol and 7-oxoroyleanone, and two new ones, 2,3-dehydrosalvipisone and 7-oxoferruginol-18-al, as well as two sesquiterpenes, caryophyllene oxide ind spathulenol, alpha-amyrin, beta-sitosterol and the flavonoids apigenin, luteolin, 4'-methylapigenin, 6-hydroxyluteolin-6,7,3',4'-tetramethyl ether, 6-hydroxy apigenin-7,4'-dimethyl ether were obtained. The diterpenoids and the sesquiterpenoids were tested for antimicrobial activity against standard bacterial strains and a yeast. 2,3-Dehydrosalvipisone, sclareol, manool, 7-oxoroyleanone, spathulenol and caryophyllene oxide were found to be active against Staphylococcus aureus, the first and third compound against Candida albicans and the last compound against Proteus mirabilis.