Mycobacterium caprae infection in humans

PRODINGER W. M., INDRA A., Koksalan O. K., Kilicaslan Z., RICHTER E.

EXPERT REVIEW OF ANTI-INFECTIVE THERAPY, cilt.12, sa.12, ss.1501-1513, 2014 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 12 Sayı: 12
  • Basım Tarihi: 2014
  • Doi Numarası: 10.1586/14787210.2014.974560
  • Dergi Adı: EXPERT REVIEW OF ANTI-INFECTIVE THERAPY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1501-1513
  • Anahtar Kelimeler: Mycobacterium caprae, epidemiology, human, Mycobacterium tuberculosis, zoonosis, BOVIS SUBSP CAPRAE, GENOTYPE MTBC ASSAY, PCR-BASED METHOD, ET-AL. 1999, TUBERCULOSIS COMPLEX, MOLECULAR EPIDEMIOLOGY, POPULATION-STRUCTURE, GENOMIC DELETIONS, LUPUS VULGARIS, CENTRAL-EUROPE
  • İstanbul Üniversitesi Adresli: Evet

Özet

Mycobacterium caprae, a member of the Mycobacterium tuberculosis complex, causes tuberculosis (TB) in man and animals. Some features distinguish M. caprae from its epidemiological twin, Mycobacterium bovis: M. caprae is evolutionarily older, accounts for a smaller burden of zoonotic TB and is not globally distributed, but primarily restricted to European countries. M. caprae occurs only in a low proportion of human TB cases and this proportion may even decrease, if progress toward eradication of animal TB in Europe continues. So why bother, if M. caprae is not an enigma for diagnostic TB tests and if resistance against first-line drugs is a rarity with M. caprae? This 'European' pathogen of zoonotic TB asks interesting questions regarding the definition of a species. The latter, seemingly only an academic question, particularly requires and challenges the collaboration between human and veterinary medicine.