The present and future disease burden of hepatitis C virus (HCV) infection with today's treatment paradigm

Razavi, H.; Waked, I.; Sarrazin, C.; Myers, R.; Idilman, R.; Calinas, F.; Vogel, W.; Mendes Correa, M.; Hezode, C.; Lazaro, P.; Akarca, U.; Aleman, S.; Balik, I.; Berg, T.; Bihl, F.; Bilodeau, M.; Blasco, A.; Brandao Mello, C.; Bruggmann, P.; Buti, M.; Calleja, J.; Cheinquer, H.; Christensen, P.; Clausen, M.; Coelho, H.; Cramp, M.; Dore, G.; Doss, W.; Duberg, A.; El-Sayed, M.; Ergor, G.; Esmat, G.; Falconer, K.; Felix, J.; Ferraz, M.; Ferreira, P.; Frankova, S.; Garcia-Samaniego, J.; Gerstoft, J.; Giria, J.; Goncales, F.; Gower, E.; Gschwantler, M.; Guimaraes Pessoa, M.; Hindman, S.; Hofer, H.; Husa, P.; Kaberg, M.; Kaita, K.; Kautz, A.; Kaymakoglu, Sabahattin; Krajden, M.; Krarup, H.; Laleman, W.; Lavanchy, D.; Marinho, R.; Marotta, P.; Mauss, S.; Moreno, C.; Murphy, K.; Negro, F.; Nemecek, V.; Ormeci, N.; Ovrehus, A.; Parkes, J.; Pasini, K.; Peltekian, K.; Ramji, A.; Reis, N.; Roberts, S.; Rosenberg, W.; Roudot-Thoraval, F.; Ryder, S.; Sarmento-Castro, R.; Semela, D.; Sherman, M.; Shiha, G.; Sievert, W.; Sperl, J.; Starkel, P.; Stauber, R.; Thompson, A.; Urbanek, P.; Van Damme, P.; van Thiel, I.; Van Vlierberghe, H.; Vandijck, D.; Wedemeyer, H.; Weis, N.; Wiegand, J.; Yosry, A.; Zekry, A.; Cornberg, M.; Muellhaupt, B.; Estes, C.

doi:10.1111/jvh.12248

The present and future disease burden of hepatitis C virus (HCV) infection with today's treatment paradigm

Atıf İçin Kopyala

Razavi H., Waked I., Sarrazin C., Myers R. P., Idilman R., Calinas F., ...Daha Fazla

JOURNAL OF VIRAL HEPATITIS, cilt.21, ss.34-59, 2014 (SCI-Expanded)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 21
Basım Tarihi: 2014
Doi Numarası: 10.1111/jvh.12248
Dergi Adı: JOURNAL OF VIRAL HEPATITIS
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.34-59
İstanbul Üniversitesi Adresli: Evet

Özet

The disease burden of hepatitis C virus (HCV) is expected to increase as the infected population ages. A modelling approach was used to estimate the total number of viremic infections, diagnosed, treated and new infections in 2013. In addition, the model was used to estimate the change in the total number of HCV infections, the disease progression and mortality in 2013-2030. Finally, expert panel consensus was used to capture current treatment practices in each country. Using today's treatment paradigm, the total number of HCV infections is projected to decline or remain flat in all countries studied. However, in the same time period, the number of individuals with late-stage liver disease is projected to increase. This study concluded that the current treatment rate and efficacy are not sufficient to manage the disease burden of HCV. Thus, alternative strategies are required to keep the number of HCV individuals with advanced liver disease and liver-related deaths from increasing.