Antimalarial agents from plants. III. Trichothecenes from Ficus fistulosa and Rhaphidophora decursiva
PLANTA MEDICA, cilt.68, sa.12, ss.1088-1091, 2002 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 68 Sayı: 12
- Basım Tarihi: 2002
- Doi Numarası: 10.1055/s-2002-36350
- Dergi Adı: PLANTA MEDICA
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.1088-1091
- Anahtar Kelimeler: Ficus fistulosa, Moraceae, Rhaphidophora decursiva, Araceae, antimalarial activity, bioassay-directed fractionation, trictiothecene sesquiterpenoids, verrucarin L acetate, roridin E
- İstanbul Üniversitesi Adresli: Evet
Özet
Bioassay-directed fractionation of an extract prepared from the dried leaves and stem barks of Ficus fistulosa Reinw. ex Blume (Moraceae) led to the isolation of verrucarin L acetate (1), together with 3alpha-hydroxyisohop-22(29)-en-24-oic acid, 3beta-gluco-sitosterol, 3,4-dihydro-6,7-dimethoxyisocarbostyril, 3,4,5-trimethoxybenzyl alcohol, alpha-methyl-3,4,5-trimethoxybenzyl alcohol, indole-3-carboxaldehyde, palmanine, and aurantiamide acetate. Roridin E (2) was identified in a subfraction from the dried leaves and stems of Rhaphidophora decursiva Schott (Araceae). Verrucarin L acetate and roridin E were characterized as macrocyclic trichothecene sesquiterpenoids and found to inhibit the growth of Plasmodium falciparum with IC50 values below I ng/ml.