HEPATIC GAMMA-GLUTAMYL CYSTEINE SYNTHETASE AND GAMMA-GLUTAMYL-TRANSPEPTIDASE ACTIVITIES IN GALACTOSAMINE TREATED RATS

SECKIN S., ALPTEKIN N., KOCAKTOKER N., UYSAL M., AYKACTOKER G.

RESEARCH COMMUNICATIONS IN MOLECULAR PATHOLOGY AND PHARMACOLOGY, cilt.87, sa.2, ss.237-240, 1995 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Kısa Makale
  • Cilt numarası: 87 Sayı: 2
  • Basım Tarihi: 1995
  • Dergi Adı: RESEARCH COMMUNICATIONS IN MOLECULAR PATHOLOGY AND PHARMACOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Aquatic Science & Fisheries Abstracts (ASFA)
  • Sayfa Sayıları: ss.237-240
  • İstanbul Üniversitesi Adresli: Evet

Özet

Liver homogenate glutathione (GSH) content, lipid peroxide levels and the activities of GSH metabolizing enzymes were studied in rats after 24 hours of galactosamine (GalN) treatment. Lipid peroxide levels increased whereas hepatic GSH content was decreased significantly. On the other hand, hepatic gamma-glutamyl cysteine synthetase activity was unaffected by GalN administration but gamma-glutamyl transpeptidase activity increased.