Serum Endocan Levels on Admission Are Associated With Worse Clinical Outcomes in COVID-19 Patients: A Pilot Study

Medetalibeyoglu A., Emet S., Kose M., Akpinar T. S., Senkal N., Catma Y., ...Daha Fazla

ANGIOLOGY, cilt.72, sa.2, ss.187-193, 2021 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 72 Sayı: 2
  • Basım Tarihi: 2021
  • Doi Numarası: 10.1177/0003319720961267
  • Dergi Adı: ANGIOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, CAB Abstracts, CINAHL, EMBASE, Food Science & Technology Abstracts, MEDLINE
  • Sayfa Sayıları: ss.187-193
  • Anahtar Kelimeler: endocan, COVID-19, SARS-CoV-2, mortality, intensive care, clinical outcome, ENDOTHELIAL-CELLS, INFECTION
  • İstanbul Üniversitesi Adresli: Evet

Özet

Thrombotic and embolic complications in the cardiovascular system are evident and associated with worse prognosis in coronavirus disease 2019 (COVID-19) patients. Endothelial-specific molecule 1 (endocan) plays a role in vascular pathology. We hypothesized serum endocan levels on admission are associated with primary composite end point (mortality and intensive care unit hospitalization) in COVID-19 patients. Patients (n = 80) with laboratory, clinical, and radiological confirmed COVID-19 were included in this cross-sectional study. Ten milliliter of peripheral venous blood were drawn within 24 hours of admission to estimate serum endocan levels. Data were analyzed using SPSS version 26.0 (IBM). Patients with the primary composite end point had significantly higher serum endocan levels than patients without (852.2 +/- 522.7 vs 550.2 +/- 440.8 ng/L, respectively;P <.01). In the logistic regression analysis, only increased serum endocan levels and increase in age were independent predictors of the primary composite end point (P< .05). In the receiver operating characteristics curve analysis, we found that a serum endocan level of 276.4 ng/L had a 97% sensitivity and 85% specificity for prediction of the primary composite end point. Baseline serum endocan levels may prove useful as a prognostic factor in patients hospitalized for COVID-19.