Polymorphisms of interferon-γ, interleukin-10, and interleukin-12 genes in myasthenia gravis

Yilmaz V., Tutuncu Y., HASBAL N. B., Parman Y., SERDAROGLU P., Deymeer F., ...Daha Fazla

Human Immunology, cilt.68, sa.6, ss.544-549, 2007 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 68 Sayı: 6
  • Basım Tarihi: 2007
  • Doi Numarası: 10.1016/j.humimm.2007.02.003
  • Dergi Adı: Human Immunology
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.544-549
  • Anahtar Kelimeler: IL-12, IL-10, IFN-gamma, myasthenia gravis, polymorphism, IL-12 P40 GENE, ACETYLCHOLINE-RECEPTOR, IFN-GAMMA, RHEUMATOID-ARTHRITIS, FLANKING REGION, T-CELLS, ASSOCIATION, DISEASE, HLA, ANTIBODIES
  • İstanbul Üniversitesi Adresli: Evet

Özet

To assess the involvement of polymorphisms in genetic susceptibility to myasthenia gravis (MG), this study analyzed four polymorphisms of interferon (IFN)-γ, interleukin (IL)-10, and IL-12 genes in 115 patients and 204 healthy controls (HC). IFNG +874T carriers were less frequent in MG, in patients with anti-acetylcholine receptor (AChR) (63%) and anti-titin (56.2%) antibodies compared with HC (p = 0.01 for all, OR: 0.5, 0.5, and 0.4, respectively). The presence of thymoma was also associated with lower frequency of IFNG +874T allele (p = 0.018, OR = 0.34). At IL10, -2763A allele was found to be slightly more frequent in MG and in patients with anti-AChR than in HC group (p = 0.05, OR = 1.7, p = 0.036, OR = 1.83). However, these associations did not remain significant after correction for multiple comparisons. IL12B allele distribution was not different among groups. These data suggest that some cytokine gene polymorphisms may contribute to susceptibility to or antibody production in MG. These findings need to be replicated in further studies. © 2007 American Society for Histocompatibility and Immunogenetics.