Cytopenia may occur in cirrhosis due to hypersplenism. However severe cytopenia is rare in cirrhosis. In this situation, together with diseases of bone marrow infiltration pernicious anemia with pancytopenia should also be considered in differential diagnosis. In literature, association of pernicious anemia and chronic liver disease was reported as a case presentation. In this paper a case with severe pancytopenia which has been proved as cryptogenic liver cirrhosis is presented.