Post-treatment circulating plasma BMP6 mRNA and H3K27 methylation levels discriminate metastatic prostate cancer from localized disease

Deligezer, UĞUR; Yaman, Fulya; Darendeliler, Mehmet; Dizdar, Yavuz; Holdenrieder, Stefan; Kovancilar, Muege; Dalay, Nejat

doi:10.1016/j.cca.2010.05.040

Post-treatment circulating plasma BMP6 mRNA and H3K27 methylation levels discriminate metastatic prostate cancer from localized disease

Deligezer U., Yaman F., Darendeliler E., Dizdar Y., Holdenrieder S., Kovancilar M., ...More

CLINICA CHIMICA ACTA, vol.411, pp.1452-1456, 2010 (SCI-Expanded, Scopus)

Publication Type: Article / Article
Volume: 411
Publication Date: 2010
Doi Number: 10.1016/j.cca.2010.05.040
Journal Name: CLINICA CHIMICA ACTA
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.1452-1456
Keywords: Prostate cancer, Metastatic disease, Plasma circulating DNA, Circulating BMP6 mRNA, Free nucleosomes, H3K27 methylation, CELL-FREE DNA, BONE MORPHOGENETIC PROTEIN-6, TUMOR-CELLS, MOLECULAR MARKER, EXPRESSION, PROGRESSION, MECHANISMS, SPREAD, SERUM
Istanbul University Affiliated: Yes

Abstract

Background: We evaluated the utility of post-treatment plasma levels of the circulating bone-morphogenetic protein-6-specific mRNA (cBMP6 mRNA), cell-free DNA (cf-DNA), apoptotic nucleosomes and Histone H3 lysine 27 trimethylation (H3K27me3), in discriminating metastatic prostate cancer (PCa) from organ confined, locally controlled disease.