Post-treatment circulating plasma BMP6 mRNA and H3K27 methylation levels discriminate metastatic prostate cancer from localized disease

Deligezer U. , Yaman F., Darendeliler E. , Dizdar Y., Holdenrieder S., Kovancilar M., ...More

CLINICA CHIMICA ACTA, vol.411, pp.1452-1456, 2010 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 411
  • Publication Date: 2010
  • Doi Number: 10.1016/j.cca.2010.05.040
  • Title of Journal : CLINICA CHIMICA ACTA
  • Page Numbers: pp.1452-1456


Background: We evaluated the utility of post-treatment plasma levels of the circulating bone-morphogenetic protein-6-specific mRNA (cBMP6 mRNA), cell-free DNA (cf-DNA), apoptotic nucleosomes and Histone H3 lysine 27 trimethylation (H3K27me3), in discriminating metastatic prostate cancer (PCa) from organ confined, locally controlled disease.