Post-treatment circulating plasma BMP6 mRNA and H3K27 methylation levels discriminate metastatic prostate cancer from localized disease

Deligezer U., Yaman F., Darendeliler E., Dizdar Y., Holdenrieder S., Kovancilar M., ...Daha Fazla

CLINICA CHIMICA ACTA, cilt.411, ss.1452-1456, 2010 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 411
  • Basım Tarihi: 2010
  • Doi Numarası: 10.1016/j.cca.2010.05.040
  • Dergi Adı: CLINICA CHIMICA ACTA
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1452-1456
  • Anahtar Kelimeler: Prostate cancer, Metastatic disease, Plasma circulating DNA, Circulating BMP6 mRNA, Free nucleosomes, H3K27 methylation, CELL-FREE DNA, BONE MORPHOGENETIC PROTEIN-6, TUMOR-CELLS, MOLECULAR MARKER, EXPRESSION, PROGRESSION, MECHANISMS, SPREAD, SERUM
  • İstanbul Üniversitesi Adresli: Evet

Özet

Background: We evaluated the utility of post-treatment plasma levels of the circulating bone-morphogenetic protein-6-specific mRNA (cBMP6 mRNA), cell-free DNA (cf-DNA), apoptotic nucleosomes and Histone H3 lysine 27 trimethylation (H3K27me3), in discriminating metastatic prostate cancer (PCa) from organ confined, locally controlled disease.