No Interaction Between Childhood Maltreatment and Serotonin Transporter Gene in Recurrent Major Depressive Disorder: A Clinical Sample

Ozcurumez G., Yurdakul H. T., Terzi Y., Direk N., Essizoglu A., Sahin F.

NOROPSIKIYATRI ARSIVI-ARCHIVES OF NEUROPSYCHIATRY, cilt.56, sa.2, ss.110-114, 2019 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 56 Sayı: 2
  • Basım Tarihi: 2019
  • Doi Numarası: 10.29399/npa.23325
  • Dergi Adı: NOROPSIKIYATRI ARSIVI-ARCHIVES OF NEUROPSYCHIATRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.110-114
  • Anahtar Kelimeler: Recurrent depression, childhood maltreatment, 5-HTTLPR, LIFE EVENTS, POLYMORPHISM, ABUSE, ASSOCIATION, MODERATION, 5-HTTLPR, STRESS, TRAUMA, ADULTS
  • İstanbul Üniversitesi Adresli: Hayır

Özet

Introduction: There is inconsistent evidence of interaction between childhood adversities and a serotonin transporter promoter polymorphism (5- HTTLPR) in depression. It is hypothesized that genetic sensitivity to stress could be more specific to recurrent major depressive disorder (MDD). The aim of the study is to replicate a recent study which provided preliminary evidence of interaction between severity of childhood maltreatment and the 5-HTTLPR polymorphism in recurrent MDD.