Is Complement Factor H Tyr402His Variant a Potential Cause of Ankylosing Spondylitis?


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PEHLİVAN S., Akaltun M. S., Pehlivan M., Gursoy S., Nursal A. F.

HASEKI TIP BULTENI-MEDICAL BULLETIN OF HASEKI, cilt.58, sa.2, ss.142-147, 2020 (ESCI) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 58 Sayı: 2
  • Basım Tarihi: 2020
  • Doi Numarası: 10.4274/haseki.galenos.2020.5783
  • Dergi Adı: HASEKI TIP BULTENI-MEDICAL BULLETIN OF HASEKI
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, Academic Search Premier, CINAHL, EMBASE, Directory of Open Access Journals, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.142-147
  • Anahtar Kelimeler: Ankylosing spondylitis, complement factor H, variant, RHEUMATOID-ARTHRITIS, SYNOVIAL-FLUIDS, ASSOCIATION, ACTIVATION, RISK, SUSCEPTIBILITY, POLYMORPHISMS, SYSTEM, GENE, DNA
  • İstanbul Üniversitesi Adresli: Evet

Özet

Aim: Ankylosing spondylitis (AS) is an autoimmune disease caused by chronic inflammatory response. Complement system is the major component of the innate immune defence. In this study, we investigated the potential association between complement factor H (CFH) gene Tyr402His variant (rs1061170) with AS in a Turkish population.