Is Complement Factor H Tyr402His Variant a Potential Cause of Ankylosing Spondylitis?

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PEHLİVAN S., Akaltun M. S., Pehlivan M., Gursoy S., Nursal A. F.

HASEKI TIP BULTENI-MEDICAL BULLETIN OF HASEKI, vol.58, no.2, pp.142-147, 2020 (ESCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 58 Issue: 2
  • Publication Date: 2020
  • Doi Number: 10.4274/haseki.galenos.2020.5783
  • Journal Name: HASEKI TIP BULTENI-MEDICAL BULLETIN OF HASEKI
  • Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus, Academic Search Premier, CINAHL, EMBASE, Directory of Open Access Journals, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.142-147
  • Keywords: Ankylosing spondylitis, complement factor H, variant, RHEUMATOID-ARTHRITIS, SYNOVIAL-FLUIDS, ASSOCIATION, ACTIVATION, RISK, SUSCEPTIBILITY, POLYMORPHISMS, SYSTEM, GENE, DNA
  • Istanbul University Affiliated: Yes

Abstract

Aim: Ankylosing spondylitis (AS) is an autoimmune disease caused by chronic inflammatory response. Complement system is the major component of the innate immune defence. In this study, we investigated the potential association between complement factor H (CFH) gene Tyr402His variant (rs1061170) with AS in a Turkish population.