Comparison of the Efficacy of HYAFF11 Mesh with Collagen Membranes in Guided Bone Regeneration
JOURNAL OF BIOMATERIALS AND TISSUE ENGINEERING, vol.12, no.11, pp.2293-2299, 2022 (SCI-Expanded)
- Publication Type: Article / Article
- Volume: 12 Issue: 11
- Publication Date: 2022
- Doi Number: 10.1166/jbt.2022.3161
- Journal Name: JOURNAL OF BIOMATERIALS AND TISSUE ENGINEERING
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), BIOSIS, Biotechnology Research Abstracts, Metadex
- Page Numbers: pp.2293-2299
- Open Archive Collection: AVESIS Open Access Collection
- Istanbul University Affiliated: Yes
Abstract
This study aimed to evaluate the efficacy of HYAFF11-based meshes in guided bone regenera-tion (GBR). Two defects of 5-mm width were prepared in the calvaria of 36 rats. The rats were divided into the following groups: empty defect (group E); HYAFF11-based mesh (group HY), colla-gen membrane (group CM), xenograft (group X), xenograft + HYAFF11 mesh (group X+ HY), and xenograft +collagen membrane (group X+CM). Sacrifications were performed at the third and sixth post-surgical weeks, followed by histological evaluation. The highest amount of new bone (NB) for-mation in the third week was observed in group X+CM (0.94+0.40 mm2), followed by group X+HY (0.80+ 0.21 mm2). The highest amount of NB formation in the sixth week was observed in group X + CM (1.57+ 0.66 mm2), followed by groups X and X + HY (1.39+ 0.48 mm2 and 1.34+0.44 mm2, respectively). There was no statistically significant difference in the amount of residual graft between groups X+HY, X+CM, and X at the third and sixth weeks. Considering the close values observed between the groups, it could be concluded that HYAFF11 may be an alternative biomate-rial for use in GBR. Further studies using different graft materials and defect sizes are required to evaluate the effectiveness of HYAFF11 in GBR.