Durable hepatitis B surface antigen decline in hepatitis B e antigen-positive chronic hepatitis B patients treated with pegylated interferon-alpha 2b: relation to response and HBV genotype

Sonneveld M. J., Rijckborst V., Cakaloglu Y., Simon K., Heathcote E. J., Tabak F., ...More

ANTIVIRAL THERAPY, vol.17, no.1, pp.9-17, 2012 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 17 Issue: 1
  • Publication Date: 2012
  • Doi Number: 10.3851/imp1887
  • Journal Name: ANTIVIRAL THERAPY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.9-17
  • Istanbul University Affiliated: Yes

Abstract

Background: On-treatment decline of serum hepatitis B surface antigen (HBsAg) may reflect the immunomodulatory effect of pegylated interferon (PEG-IFN) for hepatitis B e antigen (HBeAg)-positive chronic hepatitis B (CHB). We compared HBsAg decline across HBV genotypes between combined responders (HBeAg loss and HBV DNA < 10,000 copies/ml at week 78), HBeAg responders (HBeAg loss with HBV DNA > 10,000 copies/ml) and non-responders.