Polymorphisms in the endothelial nitric oxide synthase gene are associated with Behcet's disease

KARASNEH, JA; HAJEER, AH; SILMAN, A; WORTHINGTON, J; OLLIER, WER; Gul, AHMET

doi:10.1093/rheumatology/keh561

Polymorphisms in the endothelial nitric oxide synthase gene are associated with Behcet's disease

KARASNEH J., HAJEER A., SILMAN A., WORTHINGTON J., OLLIER W., Gul A.

RHEUMATOLOGY, vol.44, no.5, pp.614-617, 2005 (SCI-Expanded, Scopus)

Publication Type: Article / Article
Volume: 44 Issue: 5
Publication Date: 2005
Doi Number: 10.1093/rheumatology/keh561
Journal Name: RHEUMATOLOGY
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.614-617
Keywords: Behcet's disease, endothelial nitric oxide synthase gene (eNOS), single-nucleotide polymorphism, haplotype, DISEQUILIBRIUM, VASCULITIS, LINKAGE
Istanbul University Affiliated: Yes

Abstract

Objective. Reduced plasma nitric oxide (NO) levels in Behcet's disease (BD) patients have been implicated in the development of the endothelial abnormalities and thrombotic complications occurring in these patients. This study investigated the association of the endothelial NO Synthase (eNOS) gene polymorphisms with BD.