Polymorphisms in the endothelial nitric oxide synthase gene are associated with Behcet's disease

KARASNEH J., HAJEER A., SILMAN A., WORTHINGTON J., OLLIER W., Gul A.

RHEUMATOLOGY, cilt.44, sa.5, ss.614-617, 2005 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 44 Sayı: 5
  • Basım Tarihi: 2005
  • Doi Numarası: 10.1093/rheumatology/keh561
  • Dergi Adı: RHEUMATOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.614-617
  • Anahtar Kelimeler: Behcet's disease, endothelial nitric oxide synthase gene (eNOS), single-nucleotide polymorphism, haplotype, DISEQUILIBRIUM, VASCULITIS, LINKAGE
  • İstanbul Üniversitesi Adresli: Evet

Özet

Objective. Reduced plasma nitric oxide (NO) levels in Behcet's disease (BD) patients have been implicated in the development of the endothelial abnormalities and thrombotic complications occurring in these patients. This study investigated the association of the endothelial NO Synthase (eNOS) gene polymorphisms with BD.