Synthesis and investigation of antioxidant activity of the dithiocarbamate derivatives of 9,10-anthracenedione

ZVARYCH V., STASEVYCH M., Lunin V., Deniz N. G. , Sayil C., Ozyurek M., ...Daha Fazla

MONATSHEFTE FUR CHEMIE, cilt.147, sa.12, ss.2093-2101, 2016 (SCI İndekslerine Giren Dergi) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 147 Konu: 12
  • Basım Tarihi: 2016
  • Doi Numarası: 10.1007/s00706-016-1839-y
  • Sayfa Sayıları: ss.2093-2101


A variety of new derivatives of 9,10-anthracenedione with mono- and bisdithiocarbamate moiety in the non-catalytic conditions have been synthesized. The obtained compounds were screened for their antioxidant capacity using the cupric-reducing antioxidant capacity (CUPRAC) method. Three of the compounds showed CUPRAC-Trolox equivalent antioxidant capacity (TEAC) coefficients higher than trolox. Scavenging effects on reactive oxygen species (ROS), hydroxyl radical scavenging (HRS), hydrogen peroxide scavenging (HPS), and superoxide anion radical scavenging (SARS) of all synthesized compounds were determined. It was established that the results of HRS-, HPS-, and SARS-CUPRAC methods for three compounds are in accordance with TEAC-CUPRAC assay data.