Sporadic multiple cerebral cavernomatosis - Report of a case and review of literature

Coban A., Gurses C., Bilgic B., Sencer S., Karasu A., Bebek N., ...Daha Fazla

NEUROLOGIST, sa.1, ss.46-49, 2008 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Basım Tarihi: 2008
  • Doi Numarası: 10.1097/nrl.0b013e31813e343f
  • Dergi Adı: NEUROLOGIST
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.46-49
  • Anahtar Kelimeler: cavernoma, sporadic multiple malformation, liver transplantation, seizure, levetiracetam, FAMILIAL CAVERNOUS MALFORMATIONS, NATURAL-HISTORY, NERVOUS-SYSTEM, ANGIOMAS, BRAIN, HEMANGIOMAS, APPEARANCE, MUTATIONS, LESIONS, GENE
  • İstanbul Üniversitesi Adresli: Evet

Özet

Objective: Cerebral cavernous malformations (CCM) are vascular malformations causing seizures and cerebral hemorrhages. They occur in sporadic and familial forms. Familial cases are associated with a high frequency of multiple lesions, which are less frequently associated with sporadic cases. Case Report: We report a 46-year-old woman presenting with epilepsy with multiple cerebral cavernomatosis on MRI. Because she had had a previous liver transplantation operation, and received immunosuppressants, she was not advised to have a brain operation. However, she had to be operated as a result of a bleeding in one of her cerebral cavemomas. The histologic diagnosis was cavemoma. She has been seizure free after the operation with levetiracetam therapy for the last 17 months. She had no positive family history for both epilepsy and cavemomatosis. Conclusion: When multiple cerebral cavernomatosis are identified in a patient, a detailed neurologic family history should be sought despite the possibility of its being a sporadic case. Our main intention is to present a patient who is surgically controversial and to point out the importance of genetic heredity.