Clinical Features of Candidiasis in Patients With Inherited Interleukin 12 Receptor beta 1 Deficiency

OUEDERNI M., Sanal O., Ikinciogullari A., Tezcan I., Dogu F., SOLOGUREN I., ...Daha Fazla

CLINICAL INFECTIOUS DISEASES, cilt.58, sa.2, ss.204-213, 2014 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 58 Sayı: 2
  • Basım Tarihi: 2014
  • Doi Numarası: 10.1093/cid/cit722
  • Dergi Adı: CLINICAL INFECTIOUS DISEASES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.204-213
  • Anahtar Kelimeler: Interleukin-12 receptor beta 1 chain, primary immunodeficiency, Candida, Mycobacterium, Salmonella, CHRONIC MUCOCUTANEOUS CANDIDIASIS, HYPER-IGE SYNDROME, INBORN-ERRORS, IL-12R-BETA-1 DEFICIENCY, MYCOBACTERIAL DISEASE, STAT1 MUTATIONS, IL-17 IMMUNITY, DOMINANT, HUMANS, CYTOKINES
  • İstanbul Üniversitesi Adresli: Evet

Özet

Background. Interleukin 12R beta 1 (IL-12R beta 1)-deficient patients are prone to clinical disease caused by mycobacteria, Salmonella, and other intramacrophagic pathogens, probably because of impaired interleukin 12-dependent interferon gamma production. About 25% of patients also display mucocutaneous candidiasis, probably owing to impaired interleukin 23-dependent interleukin 17 immunity. The clinical features and outcome of candidiasis in these patients have not been described before, to our knowledge. We report here the clinical signs of candidiasis in 35 patients with IL-12R beta 1 deficiency.