Renal transplantation in a patient with chronic granulomatous disease: case report.

Caliskan B., Yazici H., Gulluoglu M., Caliskan Y., Turkmen A., Sever M. S.

Transplantation proceedings, cilt.47, sa.1, ss.158-60, 2015 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 47 Sayı: 1
  • Basım Tarihi: 2015
  • Doi Numarası: 10.1016/j.transproceed.2014.07.069
  • Dergi Adı: Transplantation proceedings
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.158-60
  • İstanbul Üniversitesi Adresli: Evet

Özet

Chronic granulomatous disease (CGD) is a genetic disease caused by structural mutations in the enzyme NADPH oxidase that results in severe immunodeficiency. End-stage renal disease occurs in this patient population and is attributed to various factors, including infections, amyloidosis, and nephrotoxic anti-infective agents. In this report, we present our experience in transplantation for a patient with CGD complicated by isolated hepatic tuberculosis abscess. The course of the case demonstrates the absolute requirements for a multidisciplinary and compulsive approach before, during, and after transplantation. This case report also highlights the unexpectedly benign effects of immunosuppressive therapy in this patient population.