Limbic Encephalitis Associated with Sjogren's Syndrome: Report of Three Cases

Coban A., Ozyurt S., Meric K., Misirli H., Tuzun E., Turkoglu R.

INTERNAL MEDICINE, vol.55, no.16, pp.2285-2289, 2016 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 55 Issue: 16
  • Publication Date: 2016
  • Doi Number: 10.2169/internalmedicine.55.6222
  • Journal Name: INTERNAL MEDICINE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.2285-2289
  • Keywords: limbic encephalitis, autoimmune encephalitis, Sjogren's syndrome, motor neuropathy, immunotherapy, CENTRAL-NERVOUS-SYSTEM, NEUROLOGICAL MANIFESTATIONS, NEUROPATHY, INVOLVEMENT, LESIONS
  • Istanbul University Affiliated: Yes

Abstract

Sjogren's syndrome (SS) may be complicated by neurological manifestations. We herein report three women (age range 26-60 years old) who all presented with limbic encephalitis (LE) as the predominant clinical feature 3 months to 15 years after the diagnosis of SS. The 26-year-old patient also developed acute motor axonal neuropathy one week after autoimmune encephalitis. All three patients showed contrast-enhanced MRI lesions and inflammatory cerebrospinal fluid findings, while not displaying any anti-neuronal antibodies and showing a remarkable response to immunotherapy. SS is often overlooked when the symptoms are mild. Therefore, in LE cases with no identifiable cause, serological screening for rheumatologic disorders is recommended.