Limbic Encephalitis Associated with Sjogren's Syndrome: Report of Three Cases

Coban A. , Ozyurt S., Meric K., Misirli H., Tuzun E. , Turkoglu R.

INTERNAL MEDICINE, cilt.55, ss.2285-2289, 2016 (SCI İndekslerine Giren Dergi) identifier identifier identifier


Sjogren's syndrome (SS) may be complicated by neurological manifestations. We herein report three women (age range 26-60 years old) who all presented with limbic encephalitis (LE) as the predominant clinical feature 3 months to 15 years after the diagnosis of SS. The 26-year-old patient also developed acute motor axonal neuropathy one week after autoimmune encephalitis. All three patients showed contrast-enhanced MRI lesions and inflammatory cerebrospinal fluid findings, while not displaying any anti-neuronal antibodies and showing a remarkable response to immunotherapy. SS is often overlooked when the symptoms are mild. Therefore, in LE cases with no identifiable cause, serological screening for rheumatologic disorders is recommended.