Limbic Encephalitis Associated with Sjogren's Syndrome: Report of Three Cases

Coban A., Ozyurt S., Meric K., Misirli H., Tuzun E., Turkoglu R.

INTERNAL MEDICINE, cilt.55, sa.16, ss.2285-2289, 2016 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 55 Sayı: 16
  • Basım Tarihi: 2016
  • Doi Numarası: 10.2169/internalmedicine.55.6222
  • Dergi Adı: INTERNAL MEDICINE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.2285-2289
  • Anahtar Kelimeler: limbic encephalitis, autoimmune encephalitis, Sjogren's syndrome, motor neuropathy, immunotherapy, CENTRAL-NERVOUS-SYSTEM, NEUROLOGICAL MANIFESTATIONS, NEUROPATHY, INVOLVEMENT, LESIONS
  • İstanbul Üniversitesi Adresli: Evet

Özet

Sjogren's syndrome (SS) may be complicated by neurological manifestations. We herein report three women (age range 26-60 years old) who all presented with limbic encephalitis (LE) as the predominant clinical feature 3 months to 15 years after the diagnosis of SS. The 26-year-old patient also developed acute motor axonal neuropathy one week after autoimmune encephalitis. All three patients showed contrast-enhanced MRI lesions and inflammatory cerebrospinal fluid findings, while not displaying any anti-neuronal antibodies and showing a remarkable response to immunotherapy. SS is often overlooked when the symptoms are mild. Therefore, in LE cases with no identifiable cause, serological screening for rheumatologic disorders is recommended.