Serum tumor necrosis factor-alpha and interleukin-2 concentrations in newly diagnosed ERBB2 (HER2/neu) positive breast cancer patients


Saglam S. , Suzme R. , Gurdol F.

INTERNATIONAL JOURNAL OF BIOLOGICAL MARKERS, vol.24, no.3, pp.142-146, 2009 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 24 Issue: 3
  • Publication Date: 2009
  • Doi Number: 10.5301/jbm.2009.4663
  • Title of Journal : INTERNATIONAL JOURNAL OF BIOLOGICAL MARKERS
  • Page Numbers: pp.142-146

Abstract

Aim: Cytokines have been associated with symptoms and adverse outcomes in breast cancer. Overexpression of ERBB2 (c-erb-b2; formerly HER2/neu), which is a member of the epidermal growth receptor family, is associated with involvement of lymph nodes, large tumor size, high grade, steroid receptor negativity, aneuploidy, high proliferation rate, and low overall survival in breast cancer. The aim of the study was to examine whether ERBB2 amplification has any effect on circulating levels of tumor necrosis factor-alpha (TNF-alpha) and interleukin-2 (IL-2) in breast cancer patients.