Decreased prohepcidin levels in patients with HBV-related liver disease: relation with ferritin levels.

Yonal, Oya; Akyuz, Filiz; Demir, Kadir; Ciftci, Sevgi; Keskin, Fahriye; Pinarbasi, Binnur; Uyanikoglu, Ahmet; Issever, Halim; Ozdil, Sadakat; Boztas, Gungor; Besisik, Selman; Kaymakoglu, Sabahattin; Cakaloglu, Yilmaz; Mungan, Zeynel; Okten, Atilla

doi:10.1007/s10620-010-1183-8

Decreased prohepcidin levels in patients with HBV-related liver disease: relation with ferritin levels.

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Yonal O., Akyuz F., Demir K., Ciftci S., Keskin F., Pinarbasi B., ...More

Digestive diseases and sciences, vol.55, no.12, pp.3548-51, 2010 (SCI-Expanded)

Publication Type: Article / Article
Volume: 55 Issue: 12
Publication Date: 2010
Doi Number: 10.1007/s10620-010-1183-8
Journal Name: Digestive diseases and sciences
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.3548-51
Keywords: Prohepcidin, Iron, Hepatitis B, Cirrhosis, CHRONIC HEPATITIS-C, IRON-METABOLISM, HEPCIDIN EXPRESSION, INFLAMMATION, CIRRHOSIS
Istanbul University Affiliated: Yes

Abstract

Levels of prohepcidin, a homeostatic regulator of iron absorption, are altered in chronic hepatitis C and liver cirrhosis. However, data on the potential alterations of prohepcidin in patients with HBV-related liver disease are scarce. We investigated whether serum prohepcidin is related to iron overload and perenchymal dysfuction in HBV-related liver disease.