Akademik Veri Yönetim Sistemi
JOURNAL OF MUSCULOSKELETAL & NEURONAL INTERACTIONS, cilt.23, sa.1, ss.52-60, 2023 (SCI-Expanded)
Objective: To investigate the effects of mesotherapy in patients with mild to moderate knee osteoarthritis (KOA). Methods: The study included 43 patients (56 knees) who were randomly assigned to either the mesotherapy group (MG, n=28) or the saline group (SG, n=28) and received a total of 4 weekly mesotherapy (MG) or saline injections (SG). Pain, functional status and quality of life were evaluated by a Visual Analogue Scale (VAS), the Western Ontario Universities Osteoarthritis Index (WOMAC) and the Short Form-36 (SF-36) subscales at baseline and at 8 and 16 weeks of follow-up. Results: A total of 39 patients (52 knees) completed the study. Eight weeks after treatment, a significant improvement was found in VAS pain scores, WOMAC scores and physical component scores (PCS) of the SF-36 in both groups compared to baseline (p < 0.05). The VAS activity pain score, WOMAC-pain, WOMAC-physical function and WOMAC-total scores were found to have decreased significantly in the MG compared to the SG (p < 0.001) at both 8 weeks and 16 weeks. The PCS scores significantly improved in the MG compared to the SG at 8-and 16-week follow-ups (p < 0.001 and p < 0.001, respectively). Conclusions: Mesotherapy is a well-tolerated, safe and effective alternative treatment option in patients with mild and moderate KOA.