Possible antiapoptotic and neuroprotective effects of magnesium sulphate on retina in a preterm hypoxic-ischemic rat model


Imamoglu S., Imamoglu E. Y. , Erdenoz S., CUMBUL A., Uslu F., AktaS S. , ...More

TURKISH JOURNAL OF MEDICAL SCIENCES, vol.51, no.4, pp.2198-2205, 2021 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 51 Issue: 4
  • Publication Date: 2021
  • Doi Number: 10.3906/sag-2012-119
  • Title of Journal : TURKISH JOURNAL OF MEDICAL SCIENCES
  • Page Numbers: pp.2198-2205
  • Keywords: Hypoxia-ischemia, magnesium sulfate, neuroprotection, retina, ENDOTHELIAL GROWTH-FACTOR, BRAIN-INJURY, EXPRESSION, RECEPTOR, ACTIVATION, EXPOSURE, NEURONS, PROTECT

Abstract

Background/aim: The effects of systemic magnesium sulfate (MgSO4) on retina in pretenn hypoxic-ischemic (HI) rat model are not known. Our aim was to investigate the effects of MgSO4 on retinal ganglion cell (RGC) count, retinal ganglion cell (RGC) apoptotic index, retinal vascular endothelial growth factor receptor-2 (VEGFR-2), and glial fibrillary acidic protein (GFAP) expressions in preterm HI rat model.