Topical low-dose talc is associated with early histological changes in airway anastomotic healing: A pilot rat study
CURRENT PROBLEMS IN SURGERY, cilt.78, 2026 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 78
- Basım Tarihi: 2026
- Doi Numarası: 10.1016/j.cpsurg.2026.102017
- Dergi Adı: CURRENT PROBLEMS IN SURGERY
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, MEDLINE, Directory of Open Access Journals
- İstanbul Üniversitesi Adresli: Evet
Özet
Tracheal anastomosis healing is a critical aspect of thoracic surgery, with postoperative complications such as anastomotic dehiscence and excessive fibrosis posing significant challenges. Optimizing the healing process is crucial for ensuring structural integrity and functional recovery of the airway. Various strategies have been explored to enhance tracheal healing, but an ideal method to promote both rapid and robust tissue regeneration remains elusive.1-5 Talc pleurodesis is widely used in thoracic surgery to induce pleural adhesion through an inflammatory and fibrotic response.6-8 However, the potential application of talc in tracheal anastomosis healing has not been thoroughly investigated. Given its ability to modulate local inflammatory and fibrotic reactions, talc may serve as a promising agent to enhance anastomotic integrity and accelerate healing This study aims to evaluate whether localized talc application at the tracheal anastomosis site can promote faster and stronger healing. By analyzing oxidative stress markers, inflammatory cytokines, and histopathological changes, we aim to determine the potential of talc in improving tracheal anastomosis outcomes. Additionally, we examine the PI3K/Akt/mTOR signaling pathway, which plays a crucial role in cellular proliferation and tissue remodeling, to understand the underlying mechanisms driving talc-induced healing. Although talc is classically recognized for its profibrotic effects in pleurodesis, its biological impact appears to be highly context-dependent, varying according to dose, application area, and tissue microenvironment. While diffuse pleural exposure induces robust inflammation and fibrosis, localized and low-dose application may elicit a different biological response, particularly in surgically injured tissues. To date, the effects of talc on airway anastomotic healing have not been systematically investigated.