Zinc sulfide(ZnS) nanostructures were synthesized by vapor-liquid-solid (VLS) method which is based on thermal evaporation. The morphology, chemical composition and crystal structure of ZnS nanostructures were characterized by scanning electron microscopy (SEM), energy dispersive spectroscopy (EDS) and X-ray diffraction (XRD) analyses. The results of these studies revealed that wurtzite ZnS nanowires with diameters in range of 50-400 nm are obtained. In order to investigate the humidity sensing capability, quartz crystal microbalance (QCM) and electrical resistance measurement techniques were carried out at different relative humidity (RH) conditions between 33% and 100% RH at room temperature. QCM results show that the oscillating frequency of ZnS nanowires loaded on QCM crystal decreases in range of 33-84% RH, but increases at 90% and 100% RH. The sensitivity of ZnS nanowires-based sensor (R-air/R-RH) increases over 1000 times from 33% to 100% RH. These experimental results show that ZnS nanowires have a great potential for humidity sensing applications at room temperature. (C) 2010 Elsevier B.V. All rights reserved.