COMPUTERISED DESIGNING OF DOXORUBICIN WITH BREAST CANCER CELLS


Sener L. , Gunduz S. , Şener A., Bicak B. , Kokcu Y., Ozel A. , ...Daha Fazla

JOURNAL OF ISTANBUL FACULTY OF MEDICINE-ISTANBUL TIP FAKULTESI DERGISI, cilt.82, ss.40-46, 2019 (ESCI İndekslerine Giren Dergi) identifier

  • Cilt numarası: 82 Konu: 1
  • Basım Tarihi: 2019
  • Doi Numarası: 10.26650/iuitfd.0005
  • Dergi Adı: JOURNAL OF ISTANBUL FACULTY OF MEDICINE-ISTANBUL TIP FAKULTESI DERGISI
  • Sayfa Sayıları: ss.40-46

Özet

Objective: Breast cancer is the type of cancer that starts in breast cells and has the highest incidence in the world after lung cancer. Doxorubicin is widely used in the treatment of some leukemia and Hodgkin's lymphoma, as well as in the treatment of bladder, breast, stomach, lung, ovary, thyroid, soft tissue sarcoma, multiple myeloma and other cancers. We want to determine the binding interaction of Doxorubicin in the active site of the Galectin-3 with ASN-48, ARG-32, ASN-62 and GLU-72 residues, conformation and docking score energies.