In Vitro Inhibitory Effect of Succinic Acid on T-Cell Acute Lymphoblastic Leukemia Cell Lines

Ertuğrul B., Iplik E. S., Çakmakoğlu B.

ARCHIVES OF MEDICAL RESEARCH, vol.52, no.3, pp.270-276, 2021 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 52 Issue: 3
  • Publication Date: 2021
  • Doi Number: 10.1016/j.arcmed.2020.10.022
  • Journal Name: ARCHIVES OF MEDICAL RESEARCH
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Biotechnology Research Abstracts, CAB Abstracts, EMBASE, MEDLINE, Veterinary Science Database
  • Page Numbers: pp.270-276
  • Keywords: Succinic acid, T-cell acute lymphoblastic leukemia, Apoptosis, ALPHA-TOCOPHERYL SUCCINATE, VITAMIN-E SUCCINATE, PROSTATE-CANCER, APOPTOSIS, CARCINOMA, AGENT
  • Istanbul University Affiliated: Yes

Abstract

Background and aims. Although several treatment regimens for T-cell acute lympho-blastic leukemia (T-ALL), trouble is still ongoing that relapse of disease after therapies in both pediatric and adult patients. Hence, the demand for new alternative therapeutics that are antiproliferative for cancer cells but do not harm healthy cells in treatments is increasing day by day. This study aimed to investigate whether succinic acid show anti-proliferative and apoptotic effect of on T-ALL cell lines.