Is There an Association Between Initial Clinical Manifestations and the Development of Macrophage Activation Syndrome in Patients with Systemic Juvenile Idiopathic Arthritis?

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Koker O., Ayaz N. A.

MEDICAL JOURNAL OF BAKIRKOY, vol.18, no.1, pp.31-36, 2022 (ESCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 18 Issue: 1
  • Publication Date: 2022
  • Doi Number: 10.4274/bmj.galenos.2022.2021.11-5
  • Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus, Academic Search Premier, CINAHL, EMBASE, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.31-36
  • Keywords: Arthritis, child health and disease, emergency medicine, juvenile idiopathic arthritis, macrophage activation syndrome, pediatric rheumatology, systemic juvenile idiopathic arthritis, CLASSIFICATION
  • Istanbul University Affiliated: Yes


Objective: Systemic juvenile idiopathic arthritis is deemed as a subtype of the disease complex known as juvenile idiopathic arthritis but differs in the point of its clinical manifestations and pathophysiological features. Besides, macrophage activation syndrome is a potentially fatal complication of systemic juvenile idiopathic arthritis requiring timely management. The study aims to evaluate the presence and recurrence of macrophage activation syndrome according to the initial symptoms and pattern of different phenotypes in systemic juvenile idiopathic arthritis to reveal the comprehensive association of these interrelated disorders.