Akademik Veri Yönetim Sistemi
ISOPS, Ankara, Türkiye, 25 - 28 Haziran 2024, ss.78, (Özet Bildiri)
Introduction: Ethnobotanical uses of medicinal plants have always been a good starting point for pharmacognosy research. Majority of the papers on activity of medicinal plants, especially antioxidant and antimicrobial activities, investigation of medicinal plants generally made on plants obtained from herbal markets or wild plants. Along with their highly beneficial health properties medicinal plants should be used under qualified supervision and with correct, high quality plant material. The aim of this study determination of antimicrobial and antioxidant properties of selected medicinal plants, obtained from a company that only provides to pharmacies in Turkey. Those medicinal plants were selected according to their ethnobotanical uses against infections (1-4). Materials and Methods: Lavandula intermedia, Vitis vinifera, Crataegus sp. and Capparis ovata were obtained from a company that sells only to pharmacies and has an organic agriculture certificate. The extracts of the plants were obtained by infusion method with ethanol:water (1:1) and water and subjected to investigation for antioxidant and antimicrobial activities. The extracts were investigated for their antioxidant capacities using DPPH radical scavenging activity method and CUPRAC assay. The total phenol content (TPC) References: 1. Alan et al., (2021). Clinical Phytoscience, 79(7):1-29. 2. Bulut G, Tuzlacı E (2013). Journal of Ethnopharmacology, 149(3):633–647. was spectrophotometrically determined with Folin-Ciocalteau Reagent. The extracts of the plants were evaluated for their antimicrobial activity against various bacterial and fungal strains by microdilution method, and Minimum Inhibitory Concentration (MIC, µg/mL) values were determined. Results: The results showed that the ethanolic water extract of Vitis vinifera exhibited the highest antioxidant activity with DPPH radical scavenging activity (IC50: 0,011±0,005 mg/mL), CUPRAC (0,829±0,051 mM trolox/mg extract) and TPC results (0,107±0,016 mg GAE/mg extract) than the other extracts of plants. The highest antimicrobial activity was observed in ethanolic water extract of V. vinifera against Staphylococcus epidermidis (MIC=78,12 µg/mL), Candida parapsilosis (MIC=156,25 µg/mL) and Candida tropicalis (MIC=156,25 µg/mL) strains. Conclusions: Ethanolic water extract of Vitis vinifera showed highest antioxidant and antimicrobial activity amoung the tested medicinal extracts. Due to the fact that not all chemical compounds in medicinal drugs are soluble in water, the difference between the activity results of water and ethanolic water extracts of V. vinifera was observed. 3. Cui et al., (2024). Journal of Ethnopharmacology, 319(2):117229. 4. Ikraoun et al., (2023). Tropical Journal of Natural Product Research, 7:3325-3341.