A Preliminary Investigation on the Chromosome Aberrations in Acute Lymphoblastic Leukaemia Using Multiprobe Fluorescence In Situ Hybridization Panel

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Gokkaya B., Atasoy S., ÇIRAKOĞLU A., ARGÜDEN Y., KURU R. D., YILMAZ Ş., ...Daha Fazla

BEZMIALEM SCIENCE, cilt.10, sa.3, ss.370-375, 2022 (ESCI) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 10 Sayı: 3
  • Basım Tarihi: 2022
  • Doi Numarası: 10.14235/bas.galenos.2021.5638
  • Dergi Adı: BEZMIALEM SCIENCE
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.370-375
  • Anahtar Kelimeler: Acute lymphoblastic leukemia, cytogenetics, fluorescence in situ hybridization, chromosome aberrations, IGH-AT TRANSLOCATIONS, GENETIC ABERRATIONS, FISH, REARRANGEMENTS, ABNORMALITIES, MORPHOLOGY, DIAGNOSIS, UTILITY, ADULTS
  • İstanbul Üniversitesi Adresli: Hayır

Özet

Objective: Acute lymphoblastic leukemia (ALL) is a disease related to the overproduction of immature lymphocytes. Fin diagnosis and classification of ALL, recognizing chromosome aberrations using conventional cytogenetic analysis (CCA) is essential. However, limited ability of CCA to capture cryptical chromosomal aberrations is a major drawback. The aim of this study was to investigate recurrent aberrations in patients with ALL with normal karyorype or unsuccessful karyoryping using the fluorescence in situ hybridization (FISH) method.