A Preliminary Investigation on the Chromosome Aberrations in Acute Lymphoblastic Leukaemia Using Multiprobe Fluorescence In Situ Hybridization Panel

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Gokkaya B., Atasoy S., ÇIRAKOĞLU A., ARGÜDEN Y., KURU R. D., YILMAZ Ş., ...More

BEZMIALEM SCIENCE, vol.10, no.3, pp.370-375, 2022 (ESCI) identifier

  • Publication Type: Article / Article
  • Volume: 10 Issue: 3
  • Publication Date: 2022
  • Doi Number: 10.14235/bas.galenos.2021.5638
  • Journal Name: BEZMIALEM SCIENCE
  • Journal Indexes: Emerging Sources Citation Index (ESCI), TR DİZİN (ULAKBİM)
  • Page Numbers: pp.370-375
  • Keywords: Acute lymphoblastic leukemia, cytogenetics, fluorescence in situ hybridization, chromosome aberrations, IGH-AT TRANSLOCATIONS, GENETIC ABERRATIONS, FISH, REARRANGEMENTS, ABNORMALITIES, MORPHOLOGY, DIAGNOSIS, UTILITY, ADULTS
  • Istanbul University Affiliated: No

Abstract

Objective: Acute lymphoblastic leukemia (ALL) is a disease related to the overproduction of immature lymphocytes. Fin diagnosis and classification of ALL, recognizing chromosome aberrations using conventional cytogenetic analysis (CCA) is essential. However, limited ability of CCA to capture cryptical chromosomal aberrations is a major drawback. The aim of this study was to investigate recurrent aberrations in patients with ALL with normal karyorype or unsuccessful karyoryping using the fluorescence in situ hybridization (FISH) method.