Akademik Veri Yönetim Sistemi
Journal of Cell and Molecular Biology, cilt.10, sa.1, ss.27-32, 2012 (Scopus)
Lung cancer is the second most common cancer type diagnosed and first in cancer related deaths among all cancers worldwide. The survivin gene is located on human chromosome 17q25, encoding a protein consisting of 142 amino acids. Survivin is one of the first reported inhibitors of apoptosis proteins, which is an important family of proteins that regulate apoptosis. Survivin gene polymorphism may affect the survivin production and activity, thus providing sensitivity for the development of lung cancer. The overexpression of survivin gene was found to be associated with disease development, recurrence and prognosis in various malignancies, including cancers. In this study the demonstration of the prognosis related associations between the -625G/C gene polymorphism located on the survivin promoter region and non small cell lung cancer in a Turkish population was aimed. 146 patients and 98 control subjects included to the study. PCRRFLP technique was used as the method. According to survivin -625G/C genotype distribution analysis, no statistically significant difference between patients and controls were found.