Evaluation of Hypogammaglobulinemia in Chronic Lymphocytic Leukemia Patients and Its Relation to Poor Prognostic Factors

Ayer M., Akay C. M., Ayer F. A., Ozmen D., ELİBOL T.

HASEKI TIP BULTENI-MEDICAL BULLETIN OF HASEKI, cilt.56, sa.3, ss.181-186, 2018 (ESCI) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 56 Sayı: 3
  • Basım Tarihi: 2018
  • Doi Numarası: 10.4274/haseki.85057
  • Dergi Adı: HASEKI TIP BULTENI-MEDICAL BULLETIN OF HASEKI
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.181-186
  • İstanbul Üniversitesi Adresli: Evet

Özet

Aim: Chronic lymphocytic leukemia (CLL) is a heterogenous disease with variable clinical course. Rai staging system is used for at least 40 years to predict prognosis and need for treatment but more prognostic factors are needed. Infections have been known to have a significant impact on patients with CLL. It is postulated that hypogammaglobulinemia accounts for the high infection rate. The severity of hypogammaglobulinemia is correlated with disease stage and duration.