Methylchloroisothiazolinone/methylisothiazolinone and methylisothiazolinone contact allergy: A 24-year, single-center, retrospective cohort study from Turkey

ÖZKAYA E., Kilic Sayar S., Babuna Kobaner G., PEHLİVAN G.

CONTACT DERMATITIS, vol.84, no.1, pp.24-33, 2021 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 84 Issue: 1
  • Publication Date: 2021
  • Doi Number: 10.1111/cod.13656
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, PASCAL, BIOSIS, CAB Abstracts, EMBASE, MEDLINE, Veterinary Science Database
  • Page Numbers: pp.24-33
  • Keywords: allergic contact dermatitis, cosmetics, epidemiology, methylchloroisothiazolinone, methylisothiazolinone, non-occupational, occupational, paint, patch test, prevalence, PATCH TEST SERIES, EUROPEAN-SOCIETY, DERMATITIS GROUP, EPIDEMIC, ISOTHIAZOLINONES, SENSITIZATION, MULTICENTER, RECOMMENDATION, PREVALENCE, OUTBREAK
  • Istanbul University Affiliated: Yes


Background Methylchloroisothiazolinone/methylisothiazolinone (MCI/MI) and MI allergy caused a global epidemic during the period 2010 to 2015, reaching its peak in 2013/14. Objective To investigate the characteristics of MCI/MI and MI allergy in Turkey over 24 years. Methods A total of 2310 patients patch tested between 1996 and 2019 with MCI/MI 0.01% aq. or MCI/MI 0.02% aq., with or without MI 0.2% aq., were analyzed. Results The overall prevalence of contact sensitization was 3.3% (n = 77) with a peak level of (16.4%) in 2015. The prevalence gradually decreased thereafter, but was still high (6.5%) in 2019. Seventy-three patients had clinically relevant sensitizations. MI could detect clinically relevant sensitizations in all seven patients with a negative patch test reaction to MCI/MI 0.02%. Non-occupational allergic contact dermatitis (ACD) was most frequently seen, mainly in women, with hand/face eczema from rinse-off or leave-on cosmetics, such as wet wipes. Occupational ACD was mainly seen among men with airborne eczema from wall paints in house painters, or with hand eczema from hair gel/wax in men's barbers. Conclusions The prevalence of MCI/MI and MI sensitization in Turkey following the peak in 2015 is still high. This is probably due to the currently allowed level of 100 ppm for MI in rinse-off cosmetics. This needs to be urgently reduced.